Professor Bradley Launikonis

Launikonis, Bradley S. and Murphy, Robyn M. (2025). From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals. Annual Review of Physiology. doi: 10.1146/annurev-physiol-022724-105205

Gaglianone, Rhayanna B. and Launikonis, Bradley S. (2024). Muscle fibre mitochondrial [Ca²⁺] dynamics during Ca²⁺ waves in RYR1 gain‐of‐function mouse. Acta Physiologica, 240 (3) e14098, e14098. doi: 10.1111/apha.14098

Pearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca ²⁺ entry: critical regulators of Ca ²⁺ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512

Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w

Singh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120

Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca²⁺] cause large changes in mitochondrial Ca²⁺: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022

Barclay, Christopher J. and Launikonis, Bradley S. (2022). Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c). The Journal of general physiology, 154 (9). doi: 10.1085/jgp.20211299404062022c

Barclay, Christopher J. and Launikonis, Bradley S. (2022). A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. Journal of General Physiology, 154 (9) e202112994. doi: 10.1085/jgp.202112994

Meizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J. and Launikonis, Bradley S. (2022). Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences, 119 (4) e2119203119, 1-8. doi: 10.1073/pnas.2119203119

Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412

Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166

Meizoso-Huesca, Aldo and Launikonis, Bradley S. (2021). The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. Journal of General Physiology, 153 (1) e202012747, 1-12. doi: 10.1085/jgp.202012747

Lilliu, Elena, Hilber, Karlheinz, Launikonis, Bradley S. and Koenig, Xaver (2020). Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice. Frontiers in Physiology, 11 597647, 1-11. doi: 10.3389/fphys.2020.597647

Ferreira, Juan J., Pequera, Germán, Launikonis, Bradley S., Ríos, Eduardo and Brum, Gustavo (2020). A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction. The Journal of Physiology, 599 (1) JP279917, 157-170. doi: 10.1113/jp279917

Huerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765

Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1

Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081

Barclay, C. J. and Launikonis, B. S. (2019). Components of activation heat in skeletal muscle. Journal of Muscle Research and Cell Motility, 42 (1), 1-16. doi: 10.1007/s10974-019-09547-5

Koenig, Xaver, Choi, Rocky H., Schicker, Klaus, Singh, Daniel P., Hilber, Karlheinz and Launikonis, Bradley S. (2019). Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle. Biochimica et Biophysica Acta, 1866 (7), 1239-1248. doi: 10.1016/j.bbamcr.2019.02.014

Cully, Tanya R., Choi, Rocky H., Bjorksten, Andrew R., Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2018). Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proceedings of the National Academy of Sciences of the United States of America, 115 (32), 201800490-8220. doi: 10.1073/pnas.1800490115

Koenig, Xaver, Choi, Rocky H. and Launikonis, Bradley S. (2018). Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology, 1 (1) 31, 31. doi: 10.1038/s42003-018-0033-7

Launikonis, Bradley S., Cully, Tanya R., Csernoch, Laszlo and Stephenson, D. George (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. The Journal of General Physiology, 150 (1), 95-110. doi: 10.1085/jgp.201711891

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

Choi, Rocky H., Koenig, Xaver and Launikonis, Bradley S. (2017). Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences of the United States of America, 114 (18), 4811-4815. doi: 10.1073/pnas.1619835114

Bakker, Anthony J., Cully, Tanya R., Wingate, Catherine D., Barclay, Christopher J. and Launikonis, Bradley S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149 (3), 323-334. doi: 10.1085/jgp.201611727

Cully, Tanya R., Murphy, Robyn M., Roberts, Llion, Raastad, Truls, Fassett, Robert G., Coombes, Jeff S., Jayasinghe, Isuru D. and Launikonis, Bradley S. (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nature Communications, 8 (1) 14266, 14266.1-14266.10. doi: 10.1038/ncomms14266

Cully, Tanya R., Edwards, Joshua N., Murphy, Robyn M. and Launikonis, Bradley S. (2016). A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594 (11), 2795-2810. doi: 10.1113/JP271658

Cully, Tanya R. and Launikonis, Bradley S. (2016). Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology: Cell Physiology, 310 (8), C673-C680. doi: 10.1152/ajpcell.00366.2015

Mayfield, Dean L., Launikonis, Bradley S., Cresswell, Andrew G. and Lichtwark, Glen A. (2016). Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions. Journal of Experimental Biology, 219 (22), 3587-3596. doi: 10.1242/jeb.143123

Cully, Tanya R., Edwards, Joshua N. and Launikonis, Bradley S. (2014). Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. Journal of Physiology, 592 (17), 3727-3746. doi: 10.1113/jphysiol.2014.274274

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014). Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging. Journal of the Royal Society Interface, 11 (99) 0570, 20140570. doi: 10.1098/rsif.2014.0570

Cheng, Yi-Lin, Park, Jong-Sung, Manzanero, Silvia, Choi, Yuri, Baik, Sang-Ha, Okun, Eitan, Gelderblom, Mathias, Fann, David Yang-Wei, Magnus, Tim, Launikonis, Bradley S., Mattson, Mark P., Sobey, Christopher G., Jo, Dong-Gyu and Arumugam, Thiruma V. (2014). Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiology of Disease, 62, 286-295. doi: 10.1016/j.nbd.2013.10.009

Jayasinghe, Isuru D. and Launikonis, Bradley S. (2013). Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle. Journal of Cell Science, 126 (17), 4048-4058. doi: 10.1242/jcs.131565

Jayasinghe, Isuru D., Lo, Harriet P., Morgan, Garry P., Baddeley, David, Parton, Robert G., Soeller, Christian and Launikonis, Bradley S. (2013). Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers. Biophysical Journal, 104 (11), L19-L21. doi: 10.1016/j.bpj.2013.04.029

Cully, Tanya R. and Launikonis, Bradley S. (2013). Store-operated Ca2+ entry is not required for store refilling in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 40 (5), 338-344. doi: 10.1111/1440-1681.12078

Thundyil, John, Manzanero, Silvia, Pavlovski, Dale, Cully, Tanya R., Lok, Ker-Zhing, Widiapradja, Alexander, Chunduri, Prasad, Jo, Dong-Gyu, Naruse, Chie, Asano, Masahide, Launikonis, Bradley S., Sobey, Christopher G., Coulthard, Mark G. and Arumugam, Thiruma V. (2013). Evidence that the EphA2 receptor exacerbates ischemic brain injury. PLoS One, 8 (1) e53528, e53528.1-e53528.8. doi: 10.1371/journal.pone.0053528

Ma, Yi, Zhang, Lin, Launikonis, Bradley S. and Chen, Chen (2012). Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart. Endocrinology, 153 (11), 5480-5490. doi: 10.1210/en.2012-1404

Cully, Tanya R., Edwards, Joshua N., Friedrich, Oliver, Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2012). Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.. American Journal of Physiology - Cell Physiology, 303 (5), C567-C576. doi: 10.1152/ajpcell.00144.2012

Ma, Yi, Zhang, Lin, Edwards, Joshua N., Launikonis, Breadley S. and Chen, Chen (2012). Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One, 7 (4) e35265, e35265.1-e35265.9. doi: 10.1371/journal.pone.0035265

Edwards, Joshua N., Cully, Tanya R., Shannon, Thomas R., Stephenson, D. George and Launikonis, Bradley S. (2012). Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy. Journal of Physiology, 590 (3), 475-491. doi: 10.1113/jphysiol.2011.221796

Edwards, Joshua N., Blackmore, Daniel G., Gilbert, Daniel F., Murphy, Robyn M. and Launikonis, Bradley S. (2011). Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression. Aging Cell, 10 (4), 675-685. doi: 10.1111/j.1474-9726.2011.00706.x

Launikonis, Bradley S., Murphy, Robyn M. and Edwards, Joshua N. (2010). Toward the roles of store-operated Ca(2+) entry in skeletal muscle. Pflugers Archiv - European Journal of Physiology, 460 (5), 813-823. doi: 10.1007/s00424-010-0856-7

Edwards, Joshua N., Friedrich, Oliver, Cully, Tanya R., von Wegner, Frederic, Murphy, Robyn M. and Launikonis, Bradley S. (2010). Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. American Journal of Physiology: Cell Physiology, 299 (1), C42-C50. doi: 10.1152/ajpcell.00524.2009

Edwards, Joshua N., Murphy, Robyn M., Cully, Tanya R., von Wegner, Frederic, Friedrich, Oliver and Launikonis, Bradley S. (2010). Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium, 47 (5), 458-467. doi: 10.1016/j.ceca.2010.04.001

Launikonis, Bradley S., Stephenson, D. George and Friedrich, Oliver (2009). Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle. Journal of Physiology, 587 (10), 2299-2312. doi: 10.1113/jphysiol.2009.168682

Teichmann, M D H, Wegner, F, Fink, R H A, Chamberlain, J S, Launikonis, B S, Martinac, B and Friedrich, O (2008). Inhibitory control Over Ca2+ Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression. PLoS One, 3 (11) e3644, 1-16. doi: 10.1371/journal.pone.0003644

Edwards, Joshua N. and Launikonis, Bradley S. (2008). The accessibility and interconnectivity of the tubular system network in toad skeletal muscle. The Jounal of Physiology, 586 (21), 5077-5089. doi: 10.1113/jphysiol.2008.155127

Rios, E., Zhou, J., Brum, G., Launikonis, B. S. and Stern, M. D. (2008). Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. Journal of General Physiology, 131 (4), 335-348. doi: 10.1085/jgp.200709870

Launikonis, B, Stephenson, DG and Rios, E (2007). An action potential (AP)-activated Ca2+ current in the tubular system of mammalian skeletal muscle.. Biophysical Journal, 79A-79A.

Larina, O., Bhat, P., Pickett, J. A., Launikonis, B. S., Shah, A., Kruger, W. A., Edwardson, J. M. and Thorn, P. (2007). Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells. Molecular Biology of The Cell, 18 (9), 3502-3511. doi: 10.1091/mbc.E07-01-0024

Launikonis, BS and Rios, E (2007). Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. Journal of Physiology-london, 583 (1), 81-97. doi: 10.1113/jphysiol.2007.135046

Launikonis, Bradley S., Zhou, Jingsong, Santiago, Demetrio, Brum, Gustavo and Rios, Eduardo (2006). The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle. Journal of General Physiology, 128 (1), 45-54. doi: 10.1085/jgp.200609545

Rios, E., Launikonis, B. S., Royer, L., Brum, G. and Zhou, J (2006). The elusive role of store depletion in the control of intracellular calcium release. Journal of Muscle Research And Cell Motility, 27 (5-7), 337-350. doi: 10.1007/s10974-006-9082-5

Zhou, J., Yi, J., Royer, L., Launikonis, B. S., González, A., García, J. and Ríos, E. (2006). Erratum: A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle (American Journal of Physiology - Cell Physiology (539-553) DOI: 10.1152/ajpcell.00592. 2004). American Journal of Physiology - Cell Physiology, 290 (5) doi: 10.1152/ajpcell.00054.2006

Zhou, Jingsong, Yi, Jianxun, Royer, Leandro, Launikonis, Bradley S., Gonzalez, Adom, Garcia, Jesus and Rios, Eduardo (2006). A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle. American Journal of Physiology - Cell Physiology, 290 (2), C539-C553. doi: 10.1152/ajpcell.00592.2004

Launikonis, B. S., Zhou, J. S., Royer, L., Shannon, T. R., Brum, G. and Rios, E. (2006). Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proceedings of The National Academy of Sciences of The United States of America, 103 (8), 2982-2987. doi: 10.1073/pnas.0511252103

Zhou, Jin Song, Brum, Gustavo, Gonzalez, Adom, Launikonis, Bradley S., Stern, Michael D. and Rios, Eduardo (2005). Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. Journal of General Physiology, 126 (4), 301-309. doi: 10.1085/jgp.200509353

Launikonis, Bradley S., Zhou, Jing Song, Royer, Leandro, Shannon, Thomas R., Brum, Gustavo and Rios, Eduardo (2005). Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. Journal of Physiology, 567 (2), 523-543. doi: 10.1113/jphysiol.2005.087973

Zhou, Jingsong, Launikonis, Bradley S., Rios, Eduardo and Brum, Gustavo (2004). Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?. Journal of General Physiology, 124 (4), 409-428. doi: 10.1085/jgp.200409105

Launikonis, B. S. and Stephenson, D. G. (2004). Osmotic properties of the sealed tubular system of toad and rat skeletal muscle. Journal of General Physiology, 123 (3), 231-247. doi: 10.1085/jgp.200308946

Zhou, Jin Song, Brum, Gustavo, Gonzalez, Adom, Launikonis, Bradley S., Stern, Michael D. and Rios, Eduardo (2003). Ca2+ sparks and embers of mammalian muscle. Properties of the sources. Journal of General Physiology, 122 (1), 95-114. doi: 10.1085/jgp.200308796

Launikonis, Bradley S., Barnes, Melissa and Stephenson, D. George (2003). Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor. Proceedings of The National Academy of Sciences of The United States of America, 100 (5), 2941-2944. doi: 10.1073/pnas.0536227100

Launikonis, Bradley S. and Stephenson, D. George (2002). Properties of the vertebrate skeletal muscle tubular system as a sealed compartment. Cell Biology International, 26 (10), 921-929. doi: 10.1006/cbir.2002.0942

Launikonis, Bradley S. and Stephenson, D. George (2002). Tubular system volume changes in twitch fibres from toad and rat skeletal muscle assessed by confocal microscopy. Journal of Physiology, 538 (2), 607-618. doi: 10.1013/jphysiol.2001.012920

Launikonis, Bradley S. and Stephenson, D. George (2001). Effects of membrane cholesterol manipulation on excitation-contraction coupling in skeletal muscle of the toad. Journal of Physiology, 534 (1), 71-85. doi: 10.1111/j.1469-7793.2001.00071.x

Stephenson, DG and Launikonis, B (2001). Cholesterol depletion causes depolarisation of the transverse tubular (t-) system in skeletal muscle fibres from cane toads. Journal of Physiology-london, 533, 127P-128P.

Launikonis, Bradley S. and Stephenson, D. George (2000). Effects of Mg2+ on Ca2+ release from sarcoplasmic reticulum of skeletal muscle fibres from yabby (crustacean) and rat. Journal of Physiology, 526 (2), 299-312. doi: 10.1111/j.1469-7793.2000.00299.x

Launikonis, Bradley S. and Stephenson, D. George (2000). Importance of membrane cholesterol to e-c coupling in toad skeletal muscle. Biophysical Journal, 78 (1, Part 2: 44th Annual Meeting), 369A-369A.

Launikonis, B. S. and Stephenson, D. G. (1999). Effects of beta-escin and saponin on the transverse-tubular system and sarcoplasmic reticulum membranes of rat and toad skeletal muscle. Pflugers Archiv European Journal of Physiology, 437 (6), 955-965. doi: 10.1007/s004240050867

Launikonis, Bradley S. and Stephenson, D. George (1997). Effect of saponin treatment on the sarcoplasmic reticulum of rat, cane toad and crustacean (yabby) skeletal muscle. Journal of Physiology, 504 (2), 425-437. doi: 10.1111/j.1469-7793.1997.425be.x

Singh, Daniel P., Watt, Matthew J. and Launikonis, Bradley S. (2020). Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press.

Lamboley, Cedric R., Pearce, Luke and Launikonis, Bradley S. (2020). Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle. In: 64th Annual Meeting of the Biophysical Society, San Diego, CA United States, (98A-99A). 15-19 February 2020.

Rebbeck, Robyn T., Singh, Daniel P., Ginsburg, Kenneth S., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Launikonis, Bradley S. and Cornea, Razvan L. (2019). High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March, 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2062

Barclay, Christopher J. and Launikonis, Bradley S. (2019). Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2805

Koenig, Xaver and Launikonis, Bradley S. (2018). Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 17-21, 2018. Cambridge, MA United States: Cell Press.

Rebbeck, Robyn T., Dong, Xiaoqiong, Ginsburg, Kenneth S., Singh, Daniel P., Gillispie, Gregory D., Thomas, David D., Launikonis, Bradley S., Bers, Donald M. and Cornea, Razvan L. (2018). High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications. 62nd Annual Meeting of the Biophysical Society, San Francisco, California, 17-21 February 2018. St. Louis, MO, United States: Cell Press.

Choi, Rocky H., Konig, F. Xaver, Cully, Tanya R. and Launikonis, Bradley S. (2017). Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+). 61st Annual Meeting of the Biophysical-Society, New Orleans, LA United States, Feb 11-15, 2017. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2016.11.584

Beecroft, S., Choi, R., McLean, C., Olive, M., Ryan, M., Davis, M., Laing, N., Launikonis, B. and Ravenscroft, G. (2017). Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort. 22nd International Annual Congress of the World-Muscle-Society (WMS), Saint Malo France, 3-7 October 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.nmd.2017.06.023

Koenig, X. and Launikonis, B. S. (2017). Towards the role of store-operated Ca2+ entry in skeletal muscle physiology. Joint Meeting of the Federation of European Physiological Societies and the Austrian Physiological Society with Participation of the Czech, French, Italian, Slovak, Slovenian, Swiss and Turkish Physiological Societies, Vienna, Austria, 13–15 September 2017. Chichester, West Sussex United Kingdom: Wiley.

Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375

Cully, Tanya R. and Launikonis, Bradley S. (2016). The T-System Provides a Dynamic Ca2+-Buffer in Human Skeletal Muscle Fibres. 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, Feb 27-Mar 02, 2016. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2015.11.3193

Cully, Tanya R., Choi, Rocky H., Shannon, Thomas R. and Launikonis, Bradley S. (2016). Ryanodine Receptor Activity Regulates the Levels of Ca2+ Extrusion and Store-Operated Ca2+ Entry in Skeletal Muscle. 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, Feb 27-Mar 02, 2016. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2015.11.1019

Cully, Tanya R. and Launikonis, Bradley S. (2015). Determination of the Junctional Space [Ca2+] Set by Ryanodine Receptor Leak in Slow- and Fast-Twitch Muscle Fibres. -, -, -. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2014.11.1483

Jose Ferreira, Juan, Pequera, German, Launikonis, Bradley, Rios, Eduardo and Brum, Gustavo (2014). A Chloride Channel Blocker Prevents Inorganic Phosphate Accumulation and Its Effects in the Sarcoplasmic Reticulum of Frog Permeabilized Skeletal Muscle Fibers. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.2975

Cully, Tanya R., Edwards, Joshua N., Shannon, Thomas R. and Launikonis, Bradley (2014). Ca2+ Uptake by the Tubular (T-) System Membrane of Rat Fast-Twitch Fibres. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.749

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014). Resolving the Calcium Release Machinery of Mammalian Fast- and Slow-Twitch Skeletal Muscle. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.736

Cully, Tanya R. and Launikonis, Bradley S. (2013). Store-Operated Ca2+ Entry is a Tonic and Phasic Signal in Skeletal Muscle. 57th Annual Meeting of the Biophysical Society, Philadelphia Pa, 02-06 February 2013. Maryland Heights, MO United States: Cell Press. doi: 10.1016/j.bpj.2012.11.3364

Cully, T. R., Purdue, B. W., Thomas, W. G., Gregorevic, P. and Launikonis, B. S. (2012). Injection of rAAV-Orai1 in adult wt and dystrophic mice up-regulates store operated calcium entry. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Versailles, France, 25-29 October 2012. New Rochelle, NY, United States: Mary Ann Liebert.

Ma, Y, Zhang, L, Edwards, JN, Launikonis, B and Chen, C (2011). Growth Hormone Secretagogues Preserved Normal Action Potential Pattern in Mouse Ischemia/reperfusion Cardiomyocytes In Vitro Through Modification of The Voltage-gated L Type Calcium Current and Transient Outward Potassium Current. Scientific Sessions of High Blood Pressure Research, Orlando Fl, Sep 20-24, 2011. doi: 10.1161/HYP.0b013e318234a201

Launikonis, Bradley S., Barnes, Melissa and Stephenson, D. George (2003). The skeletal muscle inositol trisphosphate receptor communicates with the plasma membrane to mediate store-operated calcium entry. 47th Annual Meeting of the Biophysical Society, San Antonio, Texas, 1-5 Mar 2003. Bethesda, MD: Biophysical Society.

Professor Bradley Launikonis

PhD and MPhil Supervision

Publications

Journal Articles

Conference Papers