Genomics of cardiovascular disease 

Human genomics has not only played a key role in understanding disease biology, but also in identifying new targets for cardiovascular drug development (e.g. PCSK9 inhibitors). Recent studies have shown that genetically validated drug targets are more likely to succeed in human clinical trials.

The ultimate goal of genetic research is to progress from genetic maps to mechanisms to medicine, and establishing a multidisciplinary network focused on cardiovascular disease will facilitate this progression. Genomic data is also increasingly being incorporated into public health research to investigate causal risk factors for disease (genetic epidemiology). and improving disease risk prediction.

Specific projects include the first large-scale genetic study of heart failure and its subtypes, and genetics of inherited cardiac disease.