Publications

Ghassabian, Sussan, Rethwan, Nur Syazwani Ahmad, Griffiths, Lyn and Smith, Maree T. (2014) Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. Journal of Chromatography B, 972 14-21. doi:10.1016/j.jchromb.2014.09.032

Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014) Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126 13-27. doi:10.1016/j.pbb.2014.09.003

Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014) Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 8: 732-740. doi:10.1097/FBP.0000000000000090

Smith, Maree T. and Muralidharan, Arjun (2014) Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain. Expert Opinion On Therapeutic Targets, 19 1: 25-35. doi:10.1517/14728222.2014.957673

Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014) Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 10: 798-806. doi:10.1111/1440-1681.12277

Kuo, Andy and Smith, Maree T. (2014) Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review. Journal of Neuroscience Methods, 233 166-171. doi:10.1016/j.jneumeth.2014.06.006

Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014) Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 2: 137-146. doi:10.1097/FBP.0000000000000025

Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014) Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 7: 2208-2219. doi:10.1016/j.bmc.2014.02.015

Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014) In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article 1-48. doi:10.1111/bph.12696

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014) Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 1: 93-110. doi:10.1111/pme.12258

Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014) Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 4: 487-511. doi:10.2217/FNL.14.33

Han, Yaqin and Smith, Maree T. (2013) Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 1-16. doi:10.3389/fphar.2013.00156

Khan, Nemat and Smith, Maree T. (2013) Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 1: 1-22. doi:10.1007/s10787-013-0195-3

Smith, Maree T. and Muralidharan, Arjun (2013) Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease". Clinical and Experimental Pharmacology and Physiology,40 11: 838-838. doi:10.1111/1440-1681.12169

Muralidharan, Arjun and Smith, Maree T. (2013) Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology, 21 5: 339-363. doi:10.1007/s10787-013-0183-7

Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157

Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013) Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 5: 692-705. doi:10.1111/pme.12063

Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013) Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 7: 1898-1904. doi:10.1016/j.bmc.2013.01.044

Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013) The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 7.1-7.10. doi:10.1186/1471-2253-13-7

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013) Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106 33-46. doi:10.1016/j.pbb.2013.02.020

Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 29.1-29.9. doi:10.1186/1471-2253-12-29

Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012) Sedation during extracorporeal membrane oxygenation-why more is less.Anaesthesia and Intensive Care, 40 6: 1067-1069.

Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012) Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 3: 726-727. doi:10.1093/jac/dks435

Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 5: R194.1-R194.7. doi:10.1186/cc11679

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 8 Article. No.e41909: . doi:10.1371/journal.pone.0041909

Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012) High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903 126-133. doi:10.1016/j.jchromb.2012.07.005

Smith, Maree T. and Moore, Brendan J. (2012) Pregabalin for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy, 13 10: 1527-1533. doi:10.1517/14656566.2012.687373

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 12: 5859-5867. doi:10.1021/jm300418d

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012) Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 2: 105-111.

Ghassabian, Sussan, Wright, Linda A., deJager, Andrew D. and Smith, Maree T. (2012) Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 881-82 34-41. doi:10.1016/j.jchromb.2011.11.031

Smith, M. T. and Muralidharan, A. (2012) Pharmacogenetics of pain and analgesia. Clinical Genetics,82 4: 321-330. doi:10.1111/j.1399-0004.2012.01936.x

Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012) Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 6: 741.e9-741.e18. doi:10.1016/j.jcrc.2012.02.013

Muralidharan, Arjun and Smith, Maree T. (2011) Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology, 63 11: 1387-1400. doi:10.1111/j.2042-7158.2011.01340.x

Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011) Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 6: 1279-1288. doi:10.1016/j.pain.2011.01.055

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 5: 782-793. doi:10.1111/j.1526-4637.2011.01102.x

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine,12 3: 437-450. doi:10.1111/j.1526-4637.2011.01067.x

Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011) PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 5: 635-642. doi:10.1038/bjc.2011.11

Smith, Maree T. and Muralidharan, Arjun (2010) Pharmacogenetics. Pain: Clinical Updates, 18 8: 1-8.

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T. and Moore, Brendan J. (2010) A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11 5: 462-471. doi:10.1016/j.jpain.2009.09.003

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J. and Smith, Maree T. (2010) Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain Medicine, 11 4: 550-561. doi:10.1111/j.1526-4637.2010.00821.x

X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009) X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry,52 22: 6991-7002. doi:10.1021/jm9003413

Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests

South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009) Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 1: 20-28. doi:10.1111/j.1440-1681.2008.05019.x

Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration

Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009) Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 4: 498-505. doi:10.1016/j.pbb.2009.06.016

Innovation in drug development

Smith, M.T. (2009) Innovation in drug development. BioSpectrum Asia CRAMS Resources Guide, 52-53.

Differences between and combinations of opiods re-visited

Smith, Maree T. (2008) Differences between and combinations of opiods re-visited. Current Opinion in Anaesthesiology, 21 5: 596-601. doi:10.1097/ACO.0b013e32830a4c4a

An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy

Zin, Che S., Nissen, Lisa M., Smith, Maree T., O'Callaghan, James P. and Moore, Brendan J. (2008) An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy.CNS Drugs, 22 5: 417-442.

Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat

Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat.Clinical and Experimental Pharmacology and Physiology, 35 3: 295-302. doi:10.1111/j.1440-1681.2007.04821.x

Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats

Edwards, S. R., Mather, L. E. and Smith, M. T. (2007) Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 5-6: 414-420. doi:10.1111/j.1440-1681.2007.04581.x

Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, Stephen R. and Smith, Maree T. (2007) Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,848 2: 264-270. doi:10.1016/j.jchromb.2006.10.039

Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain

Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007) Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 3: 289-300. doi:10.1016/j.pain.2007.03.022

Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration

Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007) Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 1065: 1063-1064. doi:10.1097/01.anes.0000265176.75372.ed

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005) Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 1-2: 112-124. doi:10.1016/j.pain.2005.08.002

Co-administration of oxycodone and morphine and analgesic synergy re-examined

Smith, MT and de la Iglesia, FA (2005) Co-administration of oxycodone and morphine and analgesic synergy re-examined. British Journal of Clinical Pharmacology, 59 4: 486-487. doi:10.1111/j.1365-2125.2005.02345_1.x

Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes

Huang, L., Edwards, S. R. and Smith, M. T. (2005) Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 9: 1489-1498. doi:10.1007/s11095-005-6154-y

Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, S. R. and Smith, M. T. (2005) Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,814 2: 241-249. doi:10.1016/j.jchromb.2004.10.035

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005) Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 5: 524-535. doi:10.1111/j.1365-2125.2005.02368.x

Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine

Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004) Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 6: 836-846. doi:10.1016/j.neuropharm.2003.11.024

Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screeningHemstapat, K, Smith, M. T. and Monteith, G. R. (2004) Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 2: 81-87. doi:10.1016/j.vascn.2003.10.002

Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones 

Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003) Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 2: 494-505. doi:10.1213/01.ANE.0000059225.40049.99

Managing diabetic neuropathy

Smith, M. T. (2003) Managing diabetic neuropathy. Australian Pharmacist, 22 10: 782-787.

The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003) The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 4: 197-200. doi:10.1034/j.1600-0773.2003.930408.x

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003) The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.Heart, Lung and Circulation, 2003 12: 44-50.

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002) The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 1-2: 119-127. doi:10.1016/S0304-3959(01)00436-5

Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance

South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001) Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.Journal of Pharmacology and Experimental Therapeutics, 297 1: 446-457.

Analgesic tolerance to opioids

South, S. M. and Smith, M. T. (2001) Analgesic tolerance to opioids. Pain: Clinical Updates, 9 5: 1-4.

Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide

Wright, AWE, Mather, LE and Smith, MT (2001) Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 4: 409-420. doi:10.1016/S0024-3205(01)01133-X

Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001) Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 6: 693-698. doi:10.1046/j.0306-5251.2001.01502.x

The role of morphine-6-glucuronide (M6G) in pain control

Smith, Maree T. and South, Samantha M. (2001) The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 3-4: 171-191. doi:10.1191/0968130201pr183ra

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000) Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 2-3: 421-428. doi:10.1016/S0304-3959(99)00230-4

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat

Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000) Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 1: 91-99.

Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites

Smith, MT (2000) Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 7: 524-528. doi:10.1046/j.1440-1681.2000.03290.x

Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats

Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000) Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 2: 236-244.

Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide

Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999) Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 2: 225-236. doi:10.1016/S0024-3205(99)00239-8

Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management

Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999) Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 1: 109-116. doi:10.1097/00000539-199901000-00021

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415.

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, HL, Cramond, T and Smith, MT (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415. doi:10.1097/00000539-199908000-00030

Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats

South, SM and Smith, MT (1998) Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats. Journal of Pharmacology And Experimental Therapeutics, 286 3: 1326-1332.

Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation

Wright, AWE, Nocente, ML and Smith, MT (1998) Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 5: 401-411. doi:10.1016/S0024-3205(98)00288-4

Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection

Wright, AWE and Smith, MT (1998) Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 20 2: 215-218. doi:10.1097/00007691-199804000-00013

Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats

Preechagoon, D, Smith, MT and Prankerd, RJ (1998) Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats. International Journal of Pharmaceutics, 163 1-2: 191-201. doi:10.1016/S0378-5173(97)00380-3

Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma

Wright, AWE, Lawrence, JA, Iu, M, Cramond, T and Smith, MT (1998) Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. Journal of Chromatography B, 712 1-2: 169-175. doi:10.1016/S0378-4347(98)00146-7

The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats

Smith, GD and Smith, MT (1998) The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology And Experimental Therapeutics, 285 3: 1157-1162.

Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide

Smith, GD, Prankerd, RJ and Smith, MT (1997) Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sciences, 61 2: 95-104. doi:10.1016/S0024-3205(97)00364-0

Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

Cabot, PJ, Cramond, T and Smith, MT (1997) Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics,10 4: 215-221. doi:10.1006/pupt.1997.0094

The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated

Ross, FB and Smith, MT (1997) The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain, 73 2: 151-157. doi:10.1016/S0304-3959(97)00093-6

Quantitative autoradiography of peripheral opioid binding sites in rat lung

Cabot, PJ, Cramond, T and Smith, MT (1996) Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 1: 47-53. doi:10.1016/0014-2999(96)00363-9

Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites

Bartlett, SE, Dodd, PR and Smith, MT (1994) Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites. Pharmacology & Toxicology, 75 2: 73-81.

Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung

Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994) Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 2: 247-255. doi:10.1016/0922-4106(94)90195-3